A significant low-pressure system will move down from the north-west of Victoria, towards the end of this week, bringing an end to settled conditions.
The Bureau of Meteorology said wet and stormy weather is redeveloping over Victoria, as a deep low pressure system interacts with humid air from the tropics.
River catchments are already wet in many areas and will be more susceptible to flooding if heavy rain develops and the Bureau says the risk will continue to be closely monitored.
BoM senior forecaster Michael Efron said the system would bring rain and isolated thunderstorms to the north, with falls of between five and 15 millimetres expected.
"There's a pretty wet stretch of weather ahead," Mr Efron said.
"Overnight that rain extends to a larger part of the northern central and eastern parts of the state.
"Friday looks like the wettest day of the outlook and we may issue warnings for heavy rainfall and damaging winds as well."
On Friday and Saturday much of the east and central parts of the state can expect windy, rainy conditions with possible thunderstorms as the low moves into the Tasman.
Daily falls of 20-60 mm are likely across the north-east and Gippsland with isolated falls of about 100 mm possible.
"Winds may have a significant impact on vegetation, given the recent rainfall that saturated soils.
"We do see that low pressure system moving away to the east on Saturday, but we are still expecting some moderate to heavy falls in eastern and central parts," Mr Efron said.
"It's still looking like a pretty wet day on Saturday."
A strong cold-front will approach from the south-west on Sunday.
'We see that front crossing the state and bringing a burst of colder air, with temperatures six to 14 degrees below average, across the state."
It was also likely to bring rain, hail and snow to Alpine areas.
Conditions would start to ease, next week.